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Interactions between remote ischemic conditioning and post-stroke sleep regulation
《医学前沿(英文)》 2021年 第15卷 第6期 页码 867-876 doi: 10.1007/s11684-021-0887-9
Genetics of ischemic and hemorrhagic stroke in Chinese population
Wei-Li ZHANG MD, PhD, Ru-Tai HUI MD, PhD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 21-28 doi: 10.1007/s11684-010-0013-x
关键词: genetics ischemic stroke hemorrhagic stroke association study
《医学前沿(英文)》 2021年 第15卷 第5期 页码 740-749 doi: 10.1007/s11684-020-0794-5
关键词: brain–computer interface functional electrical stimulation electroencephalogram laterality coefficient chronic stroke
Epidemiology, pathogenesis, and management of coronavirus disease 2019-associated stroke
《医学前沿(英文)》 doi: 10.1007/s11684-023-1041-7
关键词: SARS-CoV-2 ischemic stroke stroke hemorrhagic stroke cerebral venous thrombosis vaccination
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 20-29 doi: 10.1007/s11684-014-0371-x
Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.
关键词: cellular therapy transplantation human umbilical cord mesenchymal stem cells ischemic stroke
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 22-34 doi: 10.1007/s11684-012-0178-6
Stroke is a personal, familial, and social disaster. It is the third cause of death worldwide, the first cause of acquired disability, the second cause of dementia, and its cost is astronomic. The burden of stroke is likely to increase given the aging of the population and the growing incidence of many vascular risk factors. Prevention of stroke includes—as for all other diseases—a “mass approach” aiming at decreasing the risk at the society level and an individual approach, aiming at reducing the risk in a given subject. The mass approach is primarily based on the identification and treatment of vascular risk factors and, if possible, in the implementation of protective factors. These measures are the basis of primary prevention but most of them have now been shown to be also effective in secondary prevention. The individual approach combines a vascular risk factor modification and various treatments addressing the specific subtypes of stroke, such as antiplatelet drugs for the prevention of cerebral infarction in large and small artery diseases of the brain, carotid endarterectomy or stenting for tight carotid artery stenosis, and oral anticoagulants for the prevention of cardiac emboli. There is a growing awareness of the huge evidence-to-practice gap that exists in stroke prevention largely due to socio-economic factors. Recent approaches include low cost intervention packages to reduce blood pressure and cheap “polypills” combining in a single tablet aspirin and several drugs to lower blood pressure and cholesterol. Polypill intake should however not lead to abandon the healthy life-style measures which remain the mainstay of stroke prevention.
关键词: stroke prevention vascular risk factors cerebral infarction cerebral hemorrhage anti-thrombotic drugs carotid endarterectomy
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 432-439 doi: 10.1007/s11684-017-0511-1
Traditional Chinese patent medicines are widely used to treat stroke because it has good efficacy in the clinical environment. However, because of the lack of knowledge on traditional Chinese patent medicines, many Western physicians, who are accountable for the majority of clinical prescriptions for such medicine, are confused with the use of traditional Chinese patent medicines. Therefore, the aid-decision method is critical and necessary to help Western physicians rationally use traditional Chinese patent medicines. In this paper, Manifold Ranking is employed to develop the aid-decision model of traditional Chinese patent medicines for stroke treatment. First, 115 stroke patients from three hospitals are recruited in the cross-sectional survey. Simultaneously, traditional Chinese physicians determine the traditional Chinese patent medicines appropriate for each patient. Second, particular indicators are explored to characterize the population feature of traditional Chinese patent medicines for stroke treatment. Moreover, these particular indicators can be easily obtained by Western physicians and are feasible for widespread clinical application in the future. Third, the aid-decision model of traditional Chinese patent medicines for stroke treatment is constructed based on Manifold Ranking. Experimental results reveal that traditional Chinese patent medicines can be differentiated. Moreover, the proposed model can obtain high accuracy of aid decision.
关键词: traditional Chinese patent medicines stroke aid decision data mining manifold ranking
EEG controlled neuromuscular electrical stimulation of the upper limb for stroke patients
Hock Guan TAN, Cheng Yap SHEE, Keng He KONG, Cuntai GUAN, Wei Tech ANG
《机械工程前沿(英文)》 2011年 第6卷 第1期 页码 71-81 doi: 10.1007/s11465-011-0207-1
This paper describes the Brain Computer Interface (BCI) system and the experiments to allow post-acute (<3 months) stroke patients to use electroencephalogram (EEG) to trigger neuromuscular electrical stimulation (NMES)-assisted extension of the wrist/fingers, which are essential pre-requisites for useful hand function. EEG was recorded while subjects performed motor imagery of their paretic limb, and then analyzed to determine the optimal frequency range within the -rhythm, with the greatest attenuation. Aided by visual feedback, subjects then trained to regulate their -rhythm EEG to operate the BCI to trigger NMES of the wrist/finger. 6 post-acute stroke patients successfully completed the training, with 4 able to learn to control and use the BCI to initiate NMES. This result is consistent with the reported BCI literacy rate of healthy subjects. Thereafter, without the loss of generality, the controller of the NMES is developed and is based on a model of the upper limb muscle (biceps/triceps) groups to determine the intensity of NMES required to flex or extend the forearm by a specific angle. The muscle model is based on a phenomenological approach, with parameters that are easily measured and conveniently implemented.
关键词: brain computer interface neuromuscular electrical stimulation stroke musculoskeletal modeling
《医学前沿(英文)》 2021年 第15卷 第6期 页码 903-912 doi: 10.1007/s11684-021-0871-4
关键词: homocysteine hyperhomocysteinemia H-type hypertension Chinese
《医学前沿(英文)》 2022年 第16卷 第3期 页码 429-441 doi: 10.1007/s11684-021-0842-9
关键词: ischemic stroke microenvironment induced pluripotent stem cells (iPSCs) positron emission tomography (PET) quantitative proteomics
Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov
《医学前沿(英文)》 2019年 第13卷 第4期 页码 420-426 doi: 10.1007/s11684-019-0688-6
关键词: stroke blood–brain barrier autoimmunity innate immunity inflammation cell death
HUANG Jiuyi, WANG Guiqing, GUO Jiping, CAO Yifeng, WANG Yan, YANG Yongju, YU Xuehai
《医学前沿(英文)》 2007年 第1卷 第3期 页码 274-278 doi: 10.1007/s11684-007-0052-0
关键词: inclusion quantitative evaluation cerebrovascular relative decrease
一种高效的二冲程发动机概念——结合空气混合动力系统的增压 直流扫气式直喷汽油(BUSDIG)发动机 Review
王新颜, 赵华
《工程(英文)》 2019年 第5卷 第3期 页码 535-547 doi: 10.1016/j.eng.2019.03.008
本研究提出并设计了一种新颖的二冲程增压直流扫气式直喷汽油(BUSDIG)发动机,以实现发动机小型化和低速化,进而提升发动机的性能和效率。本文综述了BUSDIG 发动机的设计和开发过程,并总结了主要的研究成果。为了最大限度地提高发动机的扫气性能,并实现合理的缸内流动以促进燃油/ 空气的混合过程,本研究采用三维(3D)计算流体动力学(CFD)模拟手段系统分析了发动机缸径/ 冲程比(B/S)、扫气道角度和进气道的设计。此外,本研究还系统分析了扫气口和排气门开启型线对扫气过程的影响。为实现最佳的缸内燃油分层,采用经过实验标定的Reize-Diwakar模型开展了缸内喷雾的CFD 模拟,系统分析了不同喷油策略对缸内混合气形成过程的影响。基于优化后的BUSDIG 发动机设计方案,在Ricardo WAVE 软件中构建了对应的一维(1D)发动机计算模型。计算结果表明,采用稀薄燃烧和喷水策略,二冲程BUSDIG发动机的最高有效热效率可达47.2%。在化学计量燃空当量比条件下,BUSDIG 发动机在1600 r∙min–1 的转速下可实现379 N∙m 的扭矩,在4000 r∙min–1 的转速下可达到112 kW∙L–1 的功率密度。
Jiangtao YAN, Rutai HUI, Daowen WANG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 30-35 doi: 10.1007/s11684-009-0005-x
钮新强,覃利明,于庆奎
《中国工程科学》 2011年 第13卷 第7期 页码 96-103
三峡升船机具有提升重量大、升程高、上下游通航水位变幅大、水位变率快等特点,是目前世界上规模和技术难度最大的升船机。经过方案比选,三峡升船机最终确定采用齿轮齿条爬升式,其设备构造复杂,制造、安装及土建结构施工精度要求很高,并首次采用中德联合设计方式。概要介绍了三峡工程齿轮齿条爬升式升船机的总体布置、以及塔柱结构、重要设备的设计方案与关键技术。
标题 作者 时间 类型 操作
Genetics of ischemic and hemorrhagic stroke in Chinese population
Wei-Li ZHANG MD, PhD, Ru-Tai HUI MD, PhD,
期刊论文
EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and
期刊论文
Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges
null
期刊论文
A novel classification method for aid decision of traditional Chinese patent medicines for stroke treatment
null
期刊论文
EEG controlled neuromuscular electrical stimulation of the upper limb for stroke patients
Hock Guan TAN, Cheng Yap SHEE, Keng He KONG, Cuntai GUAN, Wei Tech ANG
期刊论文
Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening
期刊论文
proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke
期刊论文
Autoimmunity in acute ischemic stroke and the role of blood—brain barrier: the dark side or the light
Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov
期刊论文
Evaluation of the relative risk of stroke in patients with hypertension using cerebrovascular hemodynamic
HUANG Jiuyi, WANG Guiqing, GUO Jiping, CAO Yifeng, WANG Yan, YANG Yongju, YU Xuehai
期刊论文
Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke
Jiangtao YAN, Rutai HUI, Daowen WANG
期刊论文